Efficacy of rofecoxib and nimesulide in controlling postextraction pain in oral surgery: a randomised comparative study

Rofecoxib 50 mg/day for 6 days provided better postoperative analgesia than nimesulide 200 mg/day in a randomised trial in patients (n = 130) undergoing surgical extraction of third molars. The superiority of rofecoxib over nimesulide was especially marked during the first 2-3 postoperative days and...

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Bibliographic Details
Published inCurrent medical research and opinion Vol. 20; no. 1; p. 107
Main Authors Bracco, Pietro, Debernardi, Cesare, Coscia, Domenico, Pasqualini, Damiano, Pasqualicchio, Francesca, Calabrese, Nicola
Format Journal Article
LanguageEnglish
Published England 01.01.2004
Subjects
Adolescent
Adult
Analgesics - administration & dosage
Analgesics - therapeutic use
Anti-Inflammatory Agents, Non-Steroidal - administration & dosage
Anti-Inflammatory Agents, Non-Steroidal - therapeutic use
Female
Humans
Lactones - administration & dosage
Lactones - therapeutic use
Male
Middle Aged
Molar, Third
Pain, Postoperative - drug therapy
Sulfonamides - administration & dosage
Sulfonamides - therapeutic use
Sulfones
Tooth Extraction
Tooth, Impacted - surgery
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Summary:Rofecoxib 50 mg/day for 6 days provided better postoperative analgesia than nimesulide 200 mg/day in a randomised trial in patients (n = 130) undergoing surgical extraction of third molars. The superiority of rofecoxib over nimesulide was especially marked during the first 2-3 postoperative days and in patients with fully impacted molars. The drugs had similar effects on clinical signs of local postoperative inflammation. The effectiveness of rofecoxib in this study, plus considerations of the toxicity profile of nimesulide, support the conclusion that rofecoxib is preferable to nimesulide for relief of post-operative pain in patients undergoing surgical extraction of molars.
ISSN:0300-7995
DOI:10.1185/030079903125002694