Eosinophilic esophagogastroenteritis within the spectrum of food allergies

• Published in: Revista clínica espanõla Vol. 206; no. 5; p. 236
• Main Authors: Sánchez-Fayos Calabuig, P, Martín Relloso, M J, Porres Cubero, J C
• Format: Journal Article
• Language: Spanish
• Published: Spain 01.05.2006
• Subjects: CD4 Antigens - immunology; Eosinophils - immunology; Esophagitis, Peptic - epidemiology; Esophagitis, Peptic - immunology; Food Hypersensitivity - epidemiology; Food Hypersensitivity - immunology; Gastroenteritis - epidemiology; Gastroenteritis - immunology; Humans; Immunoglobulin E - immunology; Interleukins - immunology
• ISSN: 0014-2565
• DOI: 10.1157/13088564

Under normal conditions, the digestive tube immune system is capable of establishing an effective plan of tolerance to food that is eaten daily by the human beings. However, this tolerance plan sometimes fails and in the final steps of this immunological dysreaction, other cellular elements, usual residents of the digestive mucous, such as eosinophil granulocytes, generally participate, together with the main cells of this system. This is the case, among others, of the so-called EGE-Eos. The authors summarize the spectrum of pathogenic options of these immunological food intolerances that range from those in which "all" depend on a specific IgE (GI food anaphylaxis) and those others in which "nothing" depends on this reagin (celiac sprue). An intermediate position would be occupied by the EGE-Eos in which there seems to be overlapping of immune reactions of cellular character together with a certain role of the IgE. These pathogenic pathways frequently cross a tangle of cellular and molecular events that cannot be untangled with either an image or one thousand words.