Acquired ichthyosis revealing an Hodgkin's disease

Acquired ichthyosis is a rare condition that usually reveals malignant diseases. A 70-year-old man was admitted with weight loss, diffuse ichthyosis, lymphadenopathy of the inguinal lymph nodes and elevated inflammatory markers in peripheral blood. Histology of the lymph node revealed mixed-cellular...

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Bibliographic Details
Published inLa revue de medecine interne Vol. 29; no. 5; p. 418
Main Authors Ennibi, K, Rabhi, M, Al Bouzidi, A, Bahrouch, L, Boudlal, M, Zinebi, A, Akhouad, Y, Berady, S, Chaari, J, Toloune, F
Format Journal Article
LanguageFrench
Published France 01.05.2008
Subjects
Aged
Biomarkers - blood
Hodgkin Disease - diagnosis
Hodgkin Disease - pathology
Humans
Ichthyosis - etiology
Ichthyosis - pathology
Inflammation - pathology
Lymph Nodes - pathology
Male
Paraneoplastic Syndromes - chemically induced
Paraneoplastic Syndromes - pathology
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Summary:Acquired ichthyosis is a rare condition that usually reveals malignant diseases. A 70-year-old man was admitted with weight loss, diffuse ichthyosis, lymphadenopathy of the inguinal lymph nodes and elevated inflammatory markers in peripheral blood. Histology of the lymph node revealed mixed-cellularity Hodgkin disease. The evolution was fatal in spite of the chemotherapy. Acquired ichthyosis is a cutaneous paraneoplastic syndrome, generally related to hematologic malignancies. A possible pathomecanism is the stimulation of epidermal growth secondary to the production of epidermal growth factor (EGF) by tumour cells. Acquired ichtyosis can rarely reveal systemic or infectious diseases. It can also be drug-induced or idiopathic.
ISSN:0248-8663
DOI:10.1016/j.revmed.2007.11.015