Comparison of oncostatin M cytokine levels in saliva and serum in periodontitis: a clinicobiochemical study

• Published in: Canadian Journal of Dental Hygiene Vol. 58; no. 3; pp. 155 - 160
• Main Authors: Sonkusle, Shweta, Singh, Varsha
• Format: Journal Article Trade Publication Article
• Language: English
• Published: Canada Canadian Dental Hygienists Association 01.10.2024; CJDH
• Subjects: Adult; Alveolar bone; Arteriosclerosis; Bleeding; Bone loss; Bone resorption; Cardiovascular diseases; Case-Control Studies; Chemokines; Chemotaxis; Ciliary neurotrophic factor; Cytokines; Dendritic cells; Dental plaque; Endothelial cells; Enzyme-Linked Immunosorbent Assay; Female; Gingival index; Glycoproteins; Gum disease; Humans; Interleukin 6; Investigations; Leukemia; Leukocytes (neutrophilic); Lymphocytes T; Macrophages; Male; Melanoma; Microbiomes; Middle Aged; Neurotrophic factors; Neutrophils; Oncostatin M - blood; Oncostatin M - metabolism; Original Research; Osteoclasts; Periodontitis - blood; Periodontitis - immunology; Periodontitis - metabolism; Plaque index; Rheumatoid arthritis; Saliva - chemistry; Saliva - immunology; Sample size; Wound healing; cytokine; saliva; oncostatin M; periodontitis; biomarker; serum; interleukin-6
• ISSN: 1712-171X; 1712-1728

Oncostatin M (OSM), a 28 kDa glycoprotein 130 pleiotropic cytokine belonging to the interleukin-6 (IL-6) family, is mainly produced by neutrophils, activated T cells, monocytes, and macrophages. In response to tissue injury, it may stimulate the production of IL-6 alone or act synergistically with IL-6 or TNF-α contributing to the inflammatory cycle. Periodontitis is an inflammatory disease resulting from a dysbiotic bacterial community, which has a strong association with increased OSM production. To investigate and compare the levels of salivary and serum OSM in healthy subjects and subjects with periodontitis. Eighty-eight (88) individuals between the ages of 25 and 60 years were divided into 2 groups of 44: a periodontally healthy group (Group A) and a periodontitis group (Group B) based on clinical examination and radiographic analysis. Evaluation of salivary and serum OSM by enzyme-linked immunosorbent assay (ELISA) was performed in both groups. There was a significant difference in OSM levels between Groups A and B ( < 0.01), with higher values in Group B. There was a positive correlation between the clinical parameters and OSM levels, indicating that OSM plays a significant role in modulating the inflammatory response of periodontal tissues. The expression of cytokine OSM may play a potential role in the immunopathogenesis of periodontitis, suggesting a role as an inflammatory diagnostic marker.