1H MRSI predicts surgical outcome in MRI-negative temporal lobe epilepsy

1H MRS imaging (MRSI) was performed on 15 patients with MRI-negative temporal lobe epilepsy (TLE) who underwent seizure surgery. The non-seizure-free patients (NSF) ipsilateral hippocampal N-acetylaspartate (NAA)/(Cr+Cho) z scores were lower than the contralateral scores (p = 0.04), and the NSF ipsi...

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Published inNeurology Vol. 58; no. 5; p. 821
Main Authors Suhy, J, Laxer, K D, Capizzano, A A, Vermathen, P, Matson, G B, Barbaro, N M, Weiner, M W
Format Journal Article
LanguageEnglish
Published United States 12.03.2002
Subjects
Adult
Aspartic Acid - analogs & derivatives
Aspartic Acid - metabolism
Biomarkers
Child
Child, Preschool
Epilepsy, Temporal Lobe - pathology
Epilepsy, Temporal Lobe - physiopathology
Epilepsy, Temporal Lobe - surgery
Female
Functional Laterality
Hippocampus - metabolism
Hippocampus - pathology
Humans
Magnetic Resonance Imaging - methods
Male
Predictive Value of Tests
Statistics as Topic
Temporal Lobe - surgery
Treatment Outcome
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Summary:1H MRS imaging (MRSI) was performed on 15 patients with MRI-negative temporal lobe epilepsy (TLE) who underwent seizure surgery. The non-seizure-free patients (NSF) ipsilateral hippocampal N-acetylaspartate (NAA)/(Cr+Cho) z scores were lower than the contralateral scores (p = 0.04), and the NSF ipsilateral z scores were lower than the seizure-free patients' (SF) ipsilateral z scores (p = 0.0049). Similarly, NSF contralateral scores were lower than contralateral SF (p = 0.02). These findings suggest NAA predicts the surgical outcome in patients with TLE without evidence of mesial temporal sclerosis on MRI.
ISSN:0028-3878