Localization of endothelin-like immunoreactivity in the hypothalamo-neurohypophysial system of the rat after ischemia

Endothelin is a very powerful endogenous vasoconstrictor substance produced by endothelial cells. To examine the potential role of endothelin as a neuropeptide, we studied its distribution in the neurosecretory system. Endothelin-like immunoreactivity (EN-IR) has been demonstrated by an immunogold m...

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Published inFolia neuropathologica Vol. 34; no. 4; pp. 173 - 177
Main Authors Gajkowska, B, Viron, A
Format Journal Article
LanguageEnglish
Published Poland 1996
Subjects
Animals
Brain Ischemia - pathology
Endothelins - analysis
Hypothalamo-Hypophyseal System - chemistry
Immunohistochemistry
Male
Rats
Rats, Wistar
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Summary:Endothelin is a very powerful endogenous vasoconstrictor substance produced by endothelial cells. To examine the potential role of endothelin as a neuropeptide, we studied its distribution in the neurosecretory system. Endothelin-like immunoreactivity (EN-IR) has been demonstrated by an immunogold method in the paraventricular and supraoptic nuclear neurons and their terminals in the posterior pituitary of the rat. ET-IR was enhanced after ischemia suggesting its modulatory role in neurosecretory functions.
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ISSN:1641-4640