Asarone and its biological properties

In acute and chronic experiments on mice, rats, cats and rabbits in a wide range of tests, a study was conducted of the biological properties of alpha-asarone (1-propenyl-2,4,5- methoxybenzol)--etherophenol, isolated by the authors from the roots of Asarum europaeum. It was determined that the LD50...

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Bibliographic Details
Published inFarmakologiia i toksikologiia Vol. 48; no. 6; p. 17
Main Authors Belova, L F, Alibekov, S D, Baginskaia, A I, Sokolov, S Ia, Pokrovskaia, G V
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.11.1985
Subjects
Animals
Anisoles - pharmacology
Anisoles - therapeutic use
Anisoles - toxicity
Arteriosclerosis - drug therapy
Blood Pressure - drug effects
Catalepsy - chemically induced
Catalepsy - drug therapy
Cats
Cerebral Cortex - drug effects
Diuresis - drug effects
Drug Evaluation, Preclinical
Kidney Diseases - chemically induced
Kidney Diseases - drug therapy
Lethal Dose 50
Mice
Muscle Tonus - drug effects
Myocardial Contraction - drug effects
Plants, Medicinal
Rabbits
Rats
Respiration - drug effects
Seizures - chemically induced
Seizures - drug therapy
Stomach Ulcer - drug therapy
Stomach Ulcer - etiology
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Summary:In acute and chronic experiments on mice, rats, cats and rabbits in a wide range of tests, a study was conducted of the biological properties of alpha-asarone (1-propenyl-2,4,5- methoxybenzol)--etherophenol, isolated by the authors from the roots of Asarum europaeum. It was determined that the LD50 of asarone for mice in enteral administration was 417.6 mg/kg, in intra-abdominal--310 mg/kg. The preparation has quite diverse biological activity--tranquilizing, sedative, antiulcer, spasmolytic and antisclerosing. In its pharmacological properties the studied asarone is identical with asarone obtained from Acorus calamus and Guatteria.
ISSN:0014-8318