The immunomodulating properties of staphylotoxin

• Published in: Žurnal mikrobiologii, ėpidemiologii i immunobiologii no. 12; p. 41
• Main Authors: Bol'shakov, I N, Kulaev, D V, Kulak, V G, Lopukhin, Iu M
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 01.12.1991
• Subjects: Adjuvants, Immunologic - pharmacology; Bacterial Toxins - pharmacology; Cells, Cultured - drug effects; Cells, Cultured - immunology; Dose-Response Relationship, Drug; Humans; Receptors, Fc - drug effects; Receptors, Fc - immunology; Rosette Formation; Staphylococcus aureus; T-Lymphocytes - drug effects; T-Lymphocytes - immunology

The action of native staphylotoxin has been tested on T lymphocytes obtained from 21 healthy human donors. As revealed in this investigation, toxic action affects Fc-receptors to IgG, IgM and IgA. The dose-dependent effect of the preparation suggests its direct contacts with Fc-receptors of lymphocy...