The immunomodulating properties of staphylotoxin

The action of native staphylotoxin has been tested on T lymphocytes obtained from 21 healthy human donors. As revealed in this investigation, toxic action affects Fc-receptors to IgG, IgM and IgA. The dose-dependent effect of the preparation suggests its direct contacts with Fc-receptors of lymphocy...

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Published inŽurnal mikrobiologii, ėpidemiologii i immunobiologii no. 12; p. 41
Main Authors Bol'shakov, I N, Kulaev, D V, Kulak, V G, Lopukhin, Iu M
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.12.1991
Subjects
Adjuvants, Immunologic - pharmacology
Bacterial Toxins - pharmacology
Cells, Cultured - drug effects
Cells, Cultured - immunology
Dose-Response Relationship, Drug
Humans
Receptors, Fc - drug effects
Receptors, Fc - immunology
Rosette Formation
Staphylococcus aureus
T-Lymphocytes - drug effects
T-Lymphocytes - immunology
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Summary:The action of native staphylotoxin has been tested on T lymphocytes obtained from 21 healthy human donors. As revealed in this investigation, toxic action affects Fc-receptors to IgG, IgM and IgA. The dose-dependent effect of the preparation suggests its direct contacts with Fc-receptors of lymphocytic membranes. High doses of the toxin suppress the expression of Fc-receptors 6- to 12-fold, low doses of the toxin are capable of stimulating the expression of Fc gamma-receptors.
ISSN:0372-9311