Reference values for apolipoproteins and HDL-2/HDL-3 in childhood

It is known from epidemiological studies, that high apolipoprotein B or low HDL-2 concentrations in serum are correlated with an increased risk for premature cardiovascular diseases. It was the aim of this study to generate reference values for apolipoproteins and HDL-cholesterol fractions to accomp...

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Bibliographic Details
Published inKlinische Pädiatrie Vol. 204; no. 2; p. 102
Main Authors Schulze, S, Dörner, K
Format Journal Article
LanguageGerman
Published Germany 01.03.1992
Subjects
Apolipoproteins - blood
Arteriosclerosis - blood
Arteriosclerosis - prevention & control
Child
Child, Preschool
Cholesterol, HDL - blood
Female
Fetal Blood - metabolism
Humans
Infant
Infant, Newborn
Lipoproteins, HDL - blood
Lipoproteins, HDL2
Lipoproteins, HDL3
Male
Reference Values
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Summary:It is known from epidemiological studies, that high apolipoprotein B or low HDL-2 concentrations in serum are correlated with an increased risk for premature cardiovascular diseases. It was the aim of this study to generate reference values for apolipoproteins and HDL-cholesterol fractions to accomplish early diagnosis and therapy. All concentrations are age depending, being low at birth and increasing during the first years of life. This rise is more pronounced in apolipoprotein B than in apolipoprotein AI and HDL-2. Apolipoprotein II and HDL-3 reach later childhood values as early as at the end of the first month of life. The ratio of B and AI, which is a very good indicator for an increased risk for premature cardiovascular diseases, moves also distinctively upward during the first year of life.
ISSN:0300-8630
DOI:10.1055/s-2007-1025331