Raised serum levels of tumour necrosis factor in parasitic infections

In a study of serum levels of endogenous tumour necrosis factor (TNF) in healthy people and patients with neoplastic or infectious disease, only patients with kala-azar (visceral leishmaniasis) and malaria were found to have a strikingly increased frequency of raised TNF levels (66.6% and 70.0%, res...

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Bibliographic Details
Published inThe Lancet (British edition) Vol. 2; no. 8520; p. 1364
Main Authors Scuderi, P, Sterling, K E, Lam, K S, Finley, P R, Ryan, K J, Ray, C G, Petersen, E, Slymen, D J, Salmon, S E
Format Journal Article
LanguageEnglish
Published England 13.12.1986
Subjects
Adult
Biological Products - blood
Cytokines
Female
Glycoproteins - blood
Humans
Infant, Newborn
Leishmaniasis, Visceral - blood
Malaria - blood
Neoplasms - blood
Parasitic Diseases - blood
Pregnancy
Tumor Necrosis Factor-alpha
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Summary:In a study of serum levels of endogenous tumour necrosis factor (TNF) in healthy people and patients with neoplastic or infectious disease, only patients with kala-azar (visceral leishmaniasis) and malaria were found to have a strikingly increased frequency of raised TNF levels (66.6% and 70.0%, respectively). 7.9% of samples from both healthy subjects and patients with neoplastic disease contained measurable TNF. The discovery of elevated TNF levels in the sera of patients with parasitic diseases suggests that this cytokine may play a part in host defences against parasitic infections.
ISSN:0140-6736