Experimental study of the neurotropic activity of lithium oxybutyrate

Comparative experimental study of the known antimanic drug lithium carbonate and the original compound lithium oxybutyrate that possesses a neurotropic activity similar to that of lithium carbonate has shown lithium oxybutyrate to elicit a more prolonged and more pronounced central depressant action...

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Bibliographic Details
Published inFarmakologiia i toksikologiia Vol. 43; no. 3; p. 273
Main Authors Liubimov, B I, Tolmacheva, N S, Ostrovskaia, R U, Mitrofanov, V S
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.05.1980
Subjects
Animals
Carbonates - pharmacology
Central Nervous System - drug effects
Conditioning, Classical - drug effects
Dose-Response Relationship, Drug
Electroencephalography
Hydroxybutyrates - pharmacology
Lithium - pharmacology
Mice
Motor Activity - drug effects
Organometallic Compounds
Rabbits
Rats
Sleep - drug effects
Time Factors
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Summary:Comparative experimental study of the known antimanic drug lithium carbonate and the original compound lithium oxybutyrate that possesses a neurotropic activity similar to that of lithium carbonate has shown lithium oxybutyrate to elicit a more prolonged and more pronounced central depressant action, and a significantly less toxicity. Lithium oxybutyrate is well soluble that makes it possible to use it as injections required for rapid arrest of manic conditions.
ISSN:0014-8318