Radiation-dose dependence of the formation of micronuclei in misonidazole treated cell cultures

The effect of misonidazole at different concentrations on the anoxic radiation sensitivity of Chinese hamster cells was investigated using the frequency of radiation induced micronuclei as criterion. The result indicates that, in a high radiation dose region, sensitization with a dose modifying fact...

Full description

Saved in:
Bibliographic Details
Published inActa radiologica. Oncology Vol. 21; no. 2; p. 133
Main Author Midander, J
Format Journal Article
LanguageEnglish
Published Sweden 1982
Subjects
Animals
Cell Division - radiation effects
Cell Line
Cell Nucleus - radiation effects
Cricetinae
Cricetulus
Fibroblasts
Misonidazole - pharmacology
Nitroimidazoles - pharmacology
Radiation Dosage
Online AccessGet more information

Cover

More Information
Summary:The effect of misonidazole at different concentrations on the anoxic radiation sensitivity of Chinese hamster cells was investigated using the frequency of radiation induced micronuclei as criterion. The result indicates that, in a high radiation dose region, sensitization with a dose modifying factor of about 1.9 and 1.3 occurs after treatment with the substance at a concentration of 8 and 0.2 mmol/l, respectively. In a low dose region the corresponding values were 1.7 and 0.8. It was concluded that high concentration of the substance in combination with high radiation doses are most beneficial.
ISSN:0349-652X
DOI:10.3109/02841868209133996