Grafting of burn patients with allografts of cultured epidermal cells

Epidermal cells from cadaver skin grown in culture into confluent sheets of stratified cells were grafted on to partial thickness burn wounds in three patients. The burn areas covered with these allogeneic cultured epidermal allografts were tangentially excised deep second-degree burns which routine...

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Bibliographic Details
Published inThe Lancet (British edition) Vol. 2; no. 8347; p. 428
Main Authors Hefton, J M, Madden, M R, Finkelstein, J L, Shires, G T
Format Journal Article
LanguageEnglish
Published England 20.08.1983
Subjects
Adult
Biological Dressings
Burns - surgery
Cadaver
Cells, Cultured
Epidermal Cells
Humans
Male
Middle Aged
Skin Transplantation
Transplantation, Autologous
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Summary:Epidermal cells from cadaver skin grown in culture into confluent sheets of stratified cells were grafted on to partial thickness burn wounds in three patients. The burn areas covered with these allogeneic cultured epidermal allografts were tangentially excised deep second-degree burns which routinely would have been covered with split-thickness autografts. The burn wounds grafted with cultured allografts healed within three days and remained healthy for the 9 months of observation. Since epidermal cell cultures may be grown continuously, cultured allografts may serve as alternative biological dressings, or grafts, for deep second-degree burn wounds. They produce accelerated healing and an excellent cosmetic result, and they reduce the need for split-thickness autografts.
ISSN:0140-6736