Structure and expression of the porcine skeletal muscle ryanodine receptor gene

The ryanodine receptors (RYR) are a family of intracellular Ca2+ release channels that were first identified in the terminal cistenae of the sarcoplasmic reticulum of the skeletal and cardiac muscle. Mutations within the skeletal muscle isoform were shown to cause malignant hyperthermia in swine and...

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Published inDTW. Deutsche tierarztliche Wochenschrift Vol. 103; no. 10; p. 394
Main Authors Brenig, B, Schmoelzl, S, Leeb, T, Wen, G, Reinhart, B, Baum-Gartner, B, Krempler, A
Format Journal Article
LanguageGerman
Published Germany 01.10.1996
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Summary:The ryanodine receptors (RYR) are a family of intracellular Ca2+ release channels that were first identified in the terminal cistenae of the sarcoplasmic reticulum of the skeletal and cardiac muscle. Mutations within the skeletal muscle isoform were shown to cause malignant hyperthermia in swine and man. We have analysed the genomic structure of the porcine skeletal muscle ryanodine receptor and its expression using chimeric reporter gene constructs consisting of the RYR1 gene promoter and the chloramphenicol acetyltransferase gene after transfection in muscle and non-muscle cells.
ISSN:0341-6593