Glycemic control and lipoprotein profile in type I diabetes mellitus

To analyze the relation between the degree of glycemic control and the lipoprotein profile in type I diabetes mellitus. Seventy-five diabetics were studied in whom the total glycohemoglobin (GHb), total triglycerides (TG), triglycerides of very low density lipoproteins (TG-VLDL), total cholesterol (...

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Published inMedicina clínica Vol. 97; no. 17; p. 645
Main Authors García Pascual, L, Mesa Manteca, J, Obiols Alfonso, G, Chacón Castro, P, Campos Barreda, F, Simó Canonge, R
Format Journal Article
LanguageSpanish
Published Spain 16.11.1991
Subjects
Adolescent
Adult
Child
Cholesterol - blood
Diabetes Mellitus, Type 1 - blood
Diabetes Mellitus, Type 1 - therapy
Female
Humans
Lipoproteins - blood
Male
Middle Aged
Prospective Studies
Triglycerides - blood
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Summary:To analyze the relation between the degree of glycemic control and the lipoprotein profile in type I diabetes mellitus. Seventy-five diabetics were studied in whom the total glycohemoglobin (GHb), total triglycerides (TG), triglycerides of very low density lipoproteins (TG-VLDL), total cholesterol (TC), cholesterol of very low density lipoproteins (C-VLDL), cholesterol of high density lipoproteins (c-HDL), apolipoprotein AI (Apo AI) and apolipoprotein B (Apo B) were determined. Patients were classified according to their GHb: less than 9% (good glycemic control), 9-11% (moderate glycemic control) and greater than 11% (bad glycemic control). There was homogeneity in the 3 groups with regards to other variables which influenced the lipoprotein profile. The concentrations of TG, TG-VLDL, TC, C-VLDL and C-LDL were significantly higher in the groups of greater GHb while those of C-HDL, Apo I and Apo B were independent of the degree of glycemic control. The number of patients whose lipid profiles may be considered as atherogenic risk increases progressively in groups with greater GHb. In patients with type I diabetes mellitus, bad glycemic control is accompanied by decreases in TG, TC and C-LDL up to a magnitude which frequently reaches risk values for developing vascular disease. However, in these subjects, a less protector effect dependent on C-HDL is not to be expected since their concentrations are similar to those patients with good glycemic control.
ISSN:0025-7753