The effects of prazosin in severe congestive heart failure. An echocardiographic study

Twelve patients with severe chronic congestive heart failure (CHF) received prazosin in a dose of 4 to 20 mg daily for a period of 2 months, in addition to cardiac glycoside and diuretic drugs. After this treatment left ventricular end-diastolic diameter decreased from 5.7 +/- 0.4 to 5.4 +/- 0.4 cm...

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Bibliographic Details
Published inMedecine interne Vol. 22; no. 1; p. 29
Main Authors Drăgulescu, S I, Comşulea, L, Streian, C
Format Journal Article
LanguageEnglish
Published Romania 01.01.1984
Subjects
Adult
Aged
Digoxin - therapeutic use
Diuretics - therapeutic use
Echocardiography
Female
Heart Failure - drug therapy
Heart Failure - physiopathology
Hemodynamics - drug effects
Humans
Male
Middle Aged
Prazosin - administration & dosage
Quinazolines - administration & dosage
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Summary:Twelve patients with severe chronic congestive heart failure (CHF) received prazosin in a dose of 4 to 20 mg daily for a period of 2 months, in addition to cardiac glycoside and diuretic drugs. After this treatment left ventricular end-diastolic diameter decreased from 5.7 +/- 0.4 to 5.4 +/- 0.4 cm (p less than 0.001), left ventricular end-systolic diameter decreased from 4.3 +/- 0.5 to 4 +/- 0.5 (p less than 0.001), left ventricular stroke excursion increased from 1.03 +/- 0.11 to 1.27 +/- 0.15 cm (p less than 0.01), the ejection fraction increased from 24.9 +/- 2.1 to 32.2 +/- 2.8 (p less than 0.001) and the mean velocity of circumferential fiber shortening increased from 0.68 +/- 0.06 to 0.79 +/- 0.08 circumferences/s (p = 0.06). Prazosin treatment clearly relieved dyspnea and fatigue. Three patients improved from Class IV to Class III, four patients improved from Class IV to Class II and 3 patients from Class III to Class II.
ISSN:0377-1202