Increased level of cerebrospinal fluid beta 2-microglobulin is related to neurologic impairment in multiple sclerosis

beta 2-microglobulin was measured in the CSF of 33 MS patients (age range 26-66 years) and compared with the 95% confidence interval determined in an age-matched reference group of 32 patients without neurologic disease. Six MS (18%) had moderately increased concentrations and this subgroup was char...

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Bibliographic Details
Published inActa neurologica Scandinavica Vol. 78; no. 1; p. 72
Main Authors Bjerrum, O W, Bach, F W, Zeeberg, I
Format Journal Article
LanguageEnglish
Published Denmark 01.07.1988
Subjects
Adult
Aged
beta 2-Microglobulin - cerebrospinal fluid
Female
Humans
Male
Middle Aged
Multiple Sclerosis - cerebrospinal fluid
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Summary:beta 2-microglobulin was measured in the CSF of 33 MS patients (age range 26-66 years) and compared with the 95% confidence interval determined in an age-matched reference group of 32 patients without neurologic disease. Six MS (18%) had moderately increased concentrations and this subgroup was characterized by severe neurologic impairment according to Kurtzke's expanded disability scale. Increased CSF beta 2-microglobulin concentration in MS may reflect lesion formation.
ISSN:0001-6314
DOI:10.1111/j.1600-0404.1988.tb03622.x