Normal prostacyclinlike activity and response to plasma exchange in thrombotic thrombocytopenic purpura: report of 2 cases

2 cases of acute idiopathic thrombotic thrombocytopenic purpura are reported. Both of them were treated with plasma exchange, antiplatelet drugs and prednisolone and both completely recovered. Plasma exchange appeared to be the critical treatment. In 1 of these cases the prostacyclinlike activity re...

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Bibliographic Details
Published inActa haematologica Vol. 67; no. 3; p. 198
Main Authors Pini, M, Manotti, C, Megha, A, Poli, T, Potì, R
Format Journal Article
LanguageEnglish
Published Switzerland 1982
Subjects
Adult
Aspirin - therapeutic use
Epoprostenol - metabolism
Female
Humans
Middle Aged
Plasma Exchange
Platelet Aggregation
Prednisolone - therapeutic use
Prostaglandins - metabolism
Purpura, Thrombotic Thrombocytopenic - drug therapy
Purpura, Thrombotic Thrombocytopenic - therapy
Veins - analysis
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Summary:2 cases of acute idiopathic thrombotic thrombocytopenic purpura are reported. Both of them were treated with plasma exchange, antiplatelet drugs and prednisolone and both completely recovered. Plasma exchange appeared to be the critical treatment. In 1 of these cases the prostacyclinlike activity released from venous tissues and the ability of plasma to stimulate synthesis of prostacyclinlike activity from venous tissues exhausted after repeated washings were investigated. Both activities were detectable and comparable to those of a healthy control. These findings do not support the hypothesis of a major role played by the prostacyclin system in the pathogenesis of thrombotic thrombocytopenic purpura.
ISSN:0001-5792
DOI:10.1159/000207056