Hemophilic bleeding evaluated by blood pool scanning

The technique of blood pool scanning was used to examine 15 hemophilic subjects. Employing an in vivo method for erythrocyte labeling with Technetium-99 m, a dynamic perfusion sequence is obtained using a scintillation camera positioned over the area to be examined. This demonstrates the vascularity...

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Bibliographic Details
Published inThrombosis and haemostasis Vol. 45; no. 3; p. 208
Main Authors Green, D, Spies, S M, Rana, N A, Milgram, J W, Mintzer, R
Format Journal Article
LanguageEnglish
Published Germany 30.06.1981
Subjects
Acute Disease
Adolescent
Adult
Aged
Bioprosthesis
Child
Hemarthrosis - complications
Hemarthrosis - diagnostic imaging
Hematoma - diagnostic imaging
Hemophilia A - complications
Hemophilia A - diagnostic imaging
Hemorrhage - complications
Hemorrhage - diagnostic imaging
Humans
Knee - blood supply
Knee - diagnostic imaging
Knee Joint - blood supply
Knee Joint - surgery
Middle Aged
Radionuclide Imaging
Sodium Pertechnetate Tc 99m
Technetium
Thigh - blood supply
Tin Polyphosphates
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ISSN0340-6245

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Summary:The technique of blood pool scanning was used to examine 15 hemophilic subjects. Employing an in vivo method for erythrocyte labeling with Technetium-99 m, a dynamic perfusion sequence is obtained using a scintillation camera positioned over the area to be examined. This demonstrates the vascularity of the tissue. Subsequently, equilibrium blood pool images of the area are obtained and analyzed with a densitometer to assess relative regional blood volume. In patients who were not bleeding but had chronic arthropathy, vascularity was not increased, and the blood volume of comparable joints was similar. By contrast, marked increases in vascularity and image density were observed in studies of acutely bleeding joints. Chronic hemarthroses were associated with persistent, but less marked increases in joint perfusion. Transient increases in joint vascularity were demonstrated after insertion of knee prostheses. In a patient with a thigh hematoma, the dimensions of the hemorrhage were clearly delineated. Since only a tracer dose of nuclide is infused intravenously, there are no allergic reactions or other side effects of the procedure. Blood pool scanning is a safe, non-invasive technique that augments clinical and radiographic evaluations, and provides a new dimension in the assessment of the hemophilic patient.
ISSN:0340-6245