Alteration in content of lipids and lipoproteins in blood of rabbits with experimental allergic polyneuritis and encephalomyelitis

Experimental allergic encephalomyelitis an polyneuritis were caused in male rats of 2.5-3.0 kg body mass of the Shinshilla strain by means of administration into the foot of the animals pads of homogenous basic protein myelin from bovine spinal cord and myelin from bovine sciatic nerve as a mixture...

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Published inVoprosy meditsinskoi khimii Vol. 27; no. 3; p. 376
Main Authors Pleskov, V M, Triufanov, V F, Khitnukhin, Iu L, Konovalov, G V
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.05.1981
Subjects
Animals
Antibodies - analysis
Autoimmune Diseases - blood
Cattle
Disease Models, Animal
Encephalomyelitis, Autoimmune, Experimental - blood
Encephalomyelitis, Autoimmune, Experimental - immunology
Lipids - blood
Lipoproteins - blood
Male
Myelin Basic Protein
Polyneuropathies - blood
Polyneuropathies - immunology
Rabbits
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Summary:Experimental allergic encephalomyelitis an polyneuritis were caused in male rats of 2.5-3.0 kg body mass of the Shinshilla strain by means of administration into the foot of the animals pads of homogenous basic protein myelin from bovine spinal cord and myelin from bovine sciatic nerve as a mixture containing complete Freund's adjuvant. In the impaired rabbits total fraction of beta- and pre-beta-lipoproteins as well as content of cholesterol and triglycerides were increased in blood. Antibodies against the basic protein myelin were not found in blood of the animals with experimental allergic encephalomyelitis, whereas the titres of these antibodies were increased in the animals with experimental allergic polyneuritis. Complex formation of antibodies with beta- or pre beta-lipoproteins appears to take place in blood of the animals.
ISSN:0042-8809