Synthesis and pharmacological study of a series of 3(2H)-pyridazinones as analgesic and antiinflammatory agents

The synthesis and the pharmacological evaluation of some 3(2H)-pyridazinone derivatives are reported. The compounds were screened for analgesic, antiinflammatory and antipyretic activities. All tested derivatives showed a higher analgesic activity than phenylbutazone, while being devoid of ulcerogen...

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Bibliographic Details
Published inIl Farmaco; edizione scientifica Vol. 40; no. 12; p. 921
Main Authors Santagati, N A, Duro, F, Caruso, A, Trombadore, S, Amico-Roxas, M
Format Journal Article
LanguageEnglish
Published Italy 01.12.1985
Subjects
Animals
Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis
Anti-Inflammatory Agents, Non-Steroidal - toxicity
Behavior, Animal - drug effects
Chemical Phenomena
Chemistry
Male
Mice
Rats
Rats, Inbred Strains
Reaction Time - drug effects
Stomach Ulcer - chemically induced
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Summary:The synthesis and the pharmacological evaluation of some 3(2H)-pyridazinone derivatives are reported. The compounds were screened for analgesic, antiinflammatory and antipyretic activities. All tested derivatives showed a higher analgesic activity than phenylbutazone, while being devoid of ulcerogenic action.
ISSN:0430-0920