Bowen's disease on the sole: p16INK4a overexpression associated with human papillomavirus type 16

• Published in: British journal of dermatology (1951) Vol. 152; no. 1; pp. 170 - 173
• Main Authors: Murao, K., Kubo, Y., Takiwaki, H., Arase, S., Matsumoto, K.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Science Ltd 01.01.2005; Blackwell
• Subjects: Adult; Biological and medical sciences; Biomarkers, Tumor - metabolism; Bowen's disease; Bowen's Disease - metabolism; Bowen's Disease - virology; Cyclin-Dependent Kinase Inhibitor p16 - metabolism; Dermatology; DNA, Viral - analysis; Dyskeratosis; Female; Foot Diseases - metabolism; Foot Diseases - virology; human papillomavirus type 16; Humans; Medical sciences; p16INK4a; Papillomaviridae - classification; Papillomaviridae - isolation & purification; Papillomavirus Infections - complications; Papillomavirus Infections - virology; Skin Neoplasms - metabolism; Skin Neoplasms - virology; sole; Tumors of the skin and soft tissue. Premalignant lesions; verrucous; Human; sole; Dyskeratosis; Skin disease; Premalignant lesion; verrucoiK; Dermatology; Bowen's disease; Papovaviridae; Bowen disease; human popilloniavinis type 16; Papillomavirus; Virus; Case study; Foot sole; Human papillomavirus 16; Human papillomavirus; p16INK4a; Tumor suppressor gene
• ISSN: 0007-0963; 1365-2133
• DOI: 10.1111/j.1365-2133.2005.06365.x

Summary We report a case of Bowen's disease on the sole presenting clinically as an exophytic, blackish‐grey, verrucous tumour, and showing human papillomavirus (HPV) type 16 on analysis with polymerase chain reaction. Positive stains for HPV particles by immunohistochemical analysis were limited to several cell nuclei at the upper stratum Malpighii. However, all the tumour cells in the epidermis exhibited strong and diffuse nuclear and cytoplasmic stains for the tumour suppressor protein p16INK4a. We speculate that dysregulation of the retinoblastoma/p16INK4a pathway may be involved in the pathogenesis of the lesion, and p16INK4a overexpression might serve as a useful surrogate marker for identifying Bowen's disease harbouring high‐risk types of HPV infection.