Spontaneous fibrosarcoma in a thymus-transplanted nude mouse

A fibrosarcoma was observed in a 6-month-old nude mouse that had a neonatal thymus transplant and had been kept since birth under nearly pathogen-free conditions. This was the first tumor found in more than 1,000 nude mice maintained in a colony in which mammary carcinomas were observed among the fe...

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Bibliographic Details
Published inJNCI : Journal of the National Cancer Institute Vol. 58; no. 6; p. 1863
Main Authors Machado, E A, Lair, S V, Gregory, R S
Format Journal Article
LanguageEnglish
Published United States 01.06.1977
Subjects
Abdominal Neoplasms - immunology
Abdominal Neoplasms - pathology
Animals
Animals, Newborn
Female
Fibrosarcoma - immunology
Fibrosarcoma - pathology
Male
Mice
Mice, Nude
Thymus Gland - transplantation
Transplantation, Homologous
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Summary:A fibrosarcoma was observed in a 6-month-old nude mouse that had a neonatal thymus transplant and had been kept since birth under nearly pathogen-free conditions. This was the first tumor found in more than 1,000 nude mice maintained in a colony in which mammary carcinomas were observed among the female heterozygous breeders. This finding confirmed the fact that malignant neoplasms are rare in an animal model that lacks T-cell-mediated immunologic capability and apparently contradicted the postulates of the immunosurveillance theory.
ISSN:0027-8874
DOI:10.1093/jnci/58.6.1863