Effect of dopamine-beta-hydroxylase inhibitor (disulfiram) on the response of adenohypophysis, serum ceruloplasmin and hypothalamic ascorbic acid to estradiol treatment

The administration of tetraethylthiuramdisulfide (disulfiram, Antabus--inhibitor of dopamine-beta-hydroxylase) resulted in an inhibition of the response of anterior pituitary to estradiol (i. e. increase of weight and of binding capacity of anterior pituitary proteins to thyroxine). At the same time...

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Bibliographic Details
Published inEndocrinologia experimentalis Vol. 13; no. 3; p. 131
Main Authors Schreiber, V, Pribyl, T, Jahodová, J
Format Journal Article
LanguageEnglish
Published Slovakia 01.09.1979
Subjects
Animals
Ascorbic Acid - metabolism
Ceruloplasmin - metabolism
Disulfiram - pharmacology
Dopamine beta-Hydroxylase - antagonists & inhibitors
Drug Interactions
Estradiol - pharmacology
Hypothalamus - drug effects
Male
Pituitary Gland, Anterior - drug effects
Pituitary Hormones, Anterior - metabolism
Protein Binding
Rats
Thyroxine - metabolism
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Summary:The administration of tetraethylthiuramdisulfide (disulfiram, Antabus--inhibitor of dopamine-beta-hydroxylase) resulted in an inhibition of the response of anterior pituitary to estradiol (i. e. increase of weight and of binding capacity of anterior pituitary proteins to thyroxine). At the same time there was no inhibition of an increase of ceruloplasmin (polyphenoloxidase) level after estradiol, while a decrease of ascorbic acid in hypothalamus was fully prevented. It was concluded that disulfiram may inhibit dopamine-beta-hydroxylase activity and thus presumably protect the hypothalamic dopamine which further inhibits the response of anterior pituitary to estradiol either directly or through a dopamine dependent growth inhibiting factor.
ISSN:0013-7200