Interaction of dimethyl prostaglandin E2 and ethanol on the pancreatic secretion of the rat

We have studied the action of 16,16-dimethyl prostaglandin E2 methyl ester (DiMePGE2) on pancreatic secretion in the unanesthetized rat with pancreatic and duodenal fistulae. DiMePGE2 inhibited volume, protein secretion and bicarbonate output. The inhibition of protein concentration is dose related...

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Bibliographic Details
Published inCanadian journal of physiology and pharmacology Vol. 57; no. 2; p. 152
Main Authors Bourry, J, Demol, P, Sarles, H
Format Journal Article
LanguageFrench
Published Canada 01.02.1979
Subjects
Animals
Ethanol - antagonists & inhibitors
Ethanol - pharmacology
Injections, Intraperitoneal
Injections, Intravenous
Intubation, Gastrointestinal
Male
Pancreas - drug effects
Pancreas - metabolism
Prostaglandins E, Synthetic - administration & dosage
Prostaglandins E, Synthetic - pharmacology
Rats
Time Factors
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Summary:We have studied the action of 16,16-dimethyl prostaglandin E2 methyl ester (DiMePGE2) on pancreatic secretion in the unanesthetized rat with pancreatic and duodenal fistulae. DiMePGE2 inhibited volume, protein secretion and bicarbonate output. The inhibition of protein concentration is dose related (ED50 = 5.35 microgram/rat). DiMePGE2 was effective by the intraduodenal, intravenous, and intraperitoneal routes. Intraduodenal infusion of ethanol alone (2 mL 16% (v/v) in 1 h) strongly increased protein secretion (concentration, +30%; output, +69%) When 4 microgram DiMePGE2 was injected intraperitoneally just before the ethanol infusion, the secretory effect of ethanol disappeared and the inhibition was similar to that observed with DiMePGE2 alone.
ISSN:0008-4212
DOI:10.1139/y79-023