Bacterial Cancer

Persistent bacterial infections cause persistent irritation of the host's defense systems, which when ineffective in eradication of the infection, result in a multitude of self-destructive damages. This in some cases occurs to such severity that the resulting cellular hyper-proliferation provid...

Full description

Saved in:
Bibliographic Details
Published inIranian biomedical journal Vol. 21; no. 1; p. 1
Main Author Mohammadi, Marjan
Format Journal Article
LanguageEnglish
Published Tehran Pasteur Institute of Iran 01.01.2017
Subjects
Antigens
Bacterial infections
Gastric cancer
Genes
Infections
Inflammation
Laboratory animals
Mutation
Pathogens
Online AccessGet full text

Cover

More Information
Summary:Persistent bacterial infections cause persistent irritation of the host's defense systems, which when ineffective in eradication of the infection, result in a multitude of self-destructive damages. This in some cases occurs to such severity that the resulting cellular hyper-proliferation provides grounds for increased chances of writing errors (gene mutations) and decreased chances of corrections (gene repair). This is the basis of inflammation-induced cancer where presence of pathogens or other stimuli induce a chronic state of inflammation, yielding an array of defective cycles. Rudolph Virchow (1821-1902), a famous German pathologist, simplified "cancer" as a wound that never heals. In the case of Hp infection, the bacteria colonize a very convenient location in the stomach (underneath the mucus layer), where they firmly adhere to the apical lining of the gastric epithelium, while protected from the destructive gastric acid (by means of its alkaline producing urease) and the flood of peristalsis (by means of its multiple array of adhesins; i.e the blood group binding antigen: BabA).
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1028-852X
2008-823X