Diagnostic value of serum GP73 and AFP in hepatocellular carcinoma: a meta-analysis

• Published in: Jie fang jun yi xue za zhi Vol. 38; no. 9; p. 747
• Main Authors: Shao-hui, TANG, Sheng-lan, WU, Zheng-chang, LIN, Liang-peng, ZHANG
• Format: Journal Article
• Language: Chinese; English
• Published: Beijing People's Military Medical Press 01.01.2013
• Subjects: Full text databases; Liver cancer; Meta-analysis
• ISSN: 0577-7402

Objective　To evaluate the diagnostic value of serum Golgi protein 73 (GP73) and alpha fetoprotein (AFP) in patients with hepatocellular carcinoma (HCC). Methods　The Cochrane Central Register of Controlled Trials, PubMed, EMBase, Web of Science, Nature, Science, Springer link, Chinese Journal Full-Text Database (CNKI), Database for Chinese Technical Periodical (VIP), Wanfang Digital Journal Full-text Database (before October 2012) were retrieved to collect relevant literature in which the diagnostic value of serum GP73 and AFP in patients with HCC was evaluated. The statistical information and scientific quality were assessed and classified. The data were analyzed using Meta-Disc 1.4 software. The diagnostic value of serum GP73 and AFP in HCC was evaluated by the statistical indicators as pooled sensitivity, pooled specificity, pooled likelihood ratio and summary receiver operating characteristic curve (ROC curve). Results　Eighteen articles were collected and 5279 cases were included in the study (2075 HCC and 3204 NHCC patients). After heterogeneity test, the data were analyzed by random-effect model. The results showed that, the pooled sensitivity, specificity of the serum GP73 and AFP were 0.78(0.76-0.79) and 0.55(0.53-0.57), 0.84(0.83-0.86) and 0.80(0.78-0.81), respectively. The pooled positive likelihood ratio and negative likelihood ratio was 5.60(4.05-7.74) and 2.92(2.04-4.17), 0.28(0.24-0.32) and 0.58(0.51-0.67), respectively. The ROC area under the curve (AUC) was 0.8849 and 0.6827, and Z test showed that the difference was statistically significant (P<0.01). Conclusion　The serum GP73 has a higher sensitivity and specificity than AFP in the diagnosis of HCC, and it can be regarded as one of the valuable reference tests in patients with HCC.