Biomechanical properties of epithelial mesenchymal transition in idiopathic pulmonary fibrosis

Idiopathic pulmonary fibrosis（IPF） is a progressive scar-forming disease with a high mortality rate that has received widespread attention. Epithelial mesenchymal transition （ EMT ） is an important part of the pulmonary fibrosis process, and changes in the biomechanical properties of lung tissue hav...

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Published inSheng wu yi xue gong cheng xue za zhi Vol. 40; no. 4; pp. 632 - 637
Main Authors Li, Mingyan, Sun, Meihao, Jia, Yuanbo, Ren, Hui, Liu, Han
Format Journal Article
LanguageChinese
Published Chengdu Sichuan Society for Biomedical Engineering 25.08.2023
Subjects
Alveoli
Biomechanics
Epithelial cells
Epithelium
Fibrosis
Lung diseases
Lungs
Mechanical properties
Microenvironments
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Summary:Idiopathic pulmonary fibrosis（IPF） is a progressive scar-forming disease with a high mortality rate that has received widespread attention. Epithelial mesenchymal transition （ EMT ） is an important part of the pulmonary fibrosis process, and changes in the biomechanical properties of lung tissue have an important impact on it. In this paper,we summarize the changes in the biomechanical microenvironment of lung tissue in IPF-EMT in recent years, and provide a systematic review on the effects of alterations in the mechanical microenvironment in pulmonary fibrosis on the process of EMT, the effects of mechanical factors on the behavior of alveolar epithelial cells in EMT and the biomechanical signaling in EMT, in order to provide new references for the research on the prevention and treatment of IPF.
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ISSN:1001-5515
DOI:10.7507/1001-5515.202206016