Chemical and Biological Investigations of Albizia chinensis (Osbeck.) Merr

• Published in: Journal of physical science Vol. 25; no. 2; p. 29
• Main Authors: Sharmin, Tasnuva, Islam, Farhana, Kaisar, Mohammad A, Al-Mansur, Md Abdullah, Sikder, Md Al Amin, Rashid, Mohammad A
• Format: Journal Article
• Language: English
• Published: Pinang Universiti Sains Malaysia Press 2014
• Subjects: Antimicrobial agents; Antioxidants; Bark; Bioassays; Biocompatibility; Biological; Biological activity; Carbon; Chromatography; Correlation; Cytotoxicity; Free radicals; Herbal medicine; Methyl alcohol; NMR; Nuclear magnetic resonance; Spectrum analysis; Toxicity
• ISSN: 1675-3402; 2180-4230

A total of five compounds, namely lupeol, α-amyrin, stigmasterol, β-sitosterol and 7,3'-dimethoxyluteolin were isolated from a methanol extract of Albizia chinensis stem bark. The methanol extract of the A. chinensis stem bark and its n-hexane-, carbon tetrachloride-, chloroform- and aqueous-soluble partitionates were evaluated for antioxidant activity with 1,1-diphenyl-2-picrylhydrazyl, Folin-Ciocalteu reagent and phosphomolybdenum total antioxidant assays, where butylated hydroxytoluene and ascorbic acid were used as standards. The carbon tetrachloride-soluble fraction contained a moderate amount of phenolic compounds and it exhibited significant free radical-scavenging activity. A positive correlation was observed between the total phenolic content and the total antioxidant capacity of A. chinensis. The general toxicity was determined using a brine shrimp lethality bioassay, where the carbon tetrachloride and hexane soluble partitionates had considerable bioactive properties. The crude extract and its chloroform- and aqueous-soluble fractions displayed significant antimicrobial activity against eighteen microorganisms with inhibition zones ranging from 7.0 mm to 26.0 mm.