Comparison of the Effectiveness of Continuous versus Intermittent Cefazolin for the Prevention of Infection after Off-Pump Coronary Artery Bypass Graft

• Published in: Journal of Tehran University Heart Center Vol. 9; no. 3; p. 120
• Main Authors: ouzannia, Seyed Khalil, Karimi-Bondarabadi, Ali Akbar, Bagherinasab, Mostafa, Sarebanhassanabadi, Mohammadtaghi
• Format: Journal Article
• Language: English
• Published: Tehran Tehran University of Medical Sciences 2014
• Subjects: Antibiotics; Clinical trials; Diabetes; Disease prevention; Heart surgery; Hospitalization; Hospitals; Microorganisms; Mortality; Nosocomial infections; Postoperative period; Studies; Veins & arteries
• ISSN: 1735-8620; 2008-2371

Surgical site infection is known as a common complication after cardiac surgery, and Cefazolin is the best prophylactic antibiotic to prevent this complication. The goal of this study was to evaluate the effect of continuous and intermittent Cefazolin for the prevention of superficial surgical site infection following off-pump coronary artery bypass (OPCAB). This prospective randomized clinical trial study was conducted on 141 patients candidated for OPCAB and divided into two groups. Patients in both groups received 2 g of Cefazolin as a starting dose and at 30 minutes before incision. Hyperlipidemia, diabetes, hypertension, smoking, history of heart disease, and incidences of superficial infection were compared between the two groups. There were no significant differences in age, body surface area, duration of operation, number of distal grafts, number of proximal grafts, and duration of hospital stay before heart surgery between two groups. The incidence of infection in intermittent group was and in continuous groups was. There was no significant difference in the incidence of infection between the two groups.