Ozone Degradation of lodinated Pharmaceutical Compounds

The reactivity of a specific group of iodinated x-ray contrast media (ICM) compounds with molecular ozone and hydroxyl radicals was assessed. Determinationation of ICM compounds was carried out by HPCL coupled with ultraviolet detection. Total organic carbon of ozone solution was measured using TOC...

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Bibliographic Details
Published inJournal of environmental engineering (New York, N.Y.) Vol. 134; no. 12; pp. 944 - 953
Main Authors BO NING, GRAHAM, Nigel J. D
Format Journal Article
LanguageEnglish
Published Reston, VA American Society of Civil Engineers 01.12.2008
Subjects
Applied sciences
Exact sciences and technology
Other industrial wastes. Sewage sludge
Pollution
Wastes
Drug
Hydrogen peroxide
Laboratory scale
Ozone
Oxidant
Ozonization
Industrial waste
Halogen organic compounds
Industrial wastes
Radical mechanism
Hydroxyl radicals
pH
Oxidation
Kinetics
Rate constant
Iodine
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Summary:The reactivity of a specific group of iodinated x-ray contrast media (ICM) compounds with molecular ozone and hydroxyl radicals was assessed. Determinationation of ICM compounds was carried out by HPCL coupled with ultraviolet detection. Total organic carbon of ozone solution was measured using TOC analyser. Ozone was produced from pure medical grade oxygen using a LABO (II) ozone generator. The concentration of aqueous ozone was determined by UV spectrometry. Ozone and ozone/H sub(2)O sub(2) had the highest oxidation potential and were being considered as a means of achieving higher water quality standards. Diatrizoate was found to have a significantly lower reaction rate constant with molecular ozone than the nonionic compounds (NI-ICM) but a similar rate constant with hydroxyl radicals. The overall degradation performance of diatrizoate was low, both in absolute terms and relative to NI-ICM.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
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ISSN:0733-9372
1943-7870
DOI:10.1061/(ASCE)0733-9372(2008)134:12(944)