药对“川楝子-延胡索”治疗肝癌的网络药理学研究
目的 基于网络药理学方法研究药对“川楝子-延胡索”药理成分，分析该药对治疗肝癌的潜在分子机制。 方法 借助相关数据库如TCMSP、Uniprot、Genecard等分别搜集中药川楝子、延胡索的有效成分、对应作用靶点以及疾病肝癌的靶点，选取药物、疾病交集靶点。此外，通过String、Metascape数据库筛选药物作用核心靶点并完成GO功能和KEGG通路富集分析。 结果 中药川楝子、延胡索的有效成分分别为6、49个，共同成分1个；作用靶点分别为181、1097个，共同靶点143个；药对与肝癌的交集靶点162个，主要涉及的基因为IL6、TP53、VEGFA、TNF、CASP3；KEGG分析主要涉及...
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| Published in | Linchuang gandanbing zazhi Vol. 37; no. 9; pp. 2136 - 2143 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | Chinese |
| Published |
Changchun
Journal of Clinical Hepatology
01.09.2021
贵州中医药大学研究生院,贵阳550025%贵州中医药大学第一附属医院肿瘤科,贵阳550001 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1001-5256 2097-3497 |
| DOI | 10.3969/j.issn.1001-5256.2021.09.026 |
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| Abstract | 目的 基于网络药理学方法研究药对“川楝子-延胡索”药理成分，分析该药对治疗肝癌的潜在分子机制。 方法 借助相关数据库如TCMSP、Uniprot、Genecard等分别搜集中药川楝子、延胡索的有效成分、对应作用靶点以及疾病肝癌的靶点，选取药物、疾病交集靶点。此外，通过String、Metascape数据库筛选药物作用核心靶点并完成GO功能和KEGG通路富集分析。 结果 中药川楝子、延胡索的有效成分分别为6、49个，共同成分1个；作用靶点分别为181、1097个，共同靶点143个；药对与肝癌的交集靶点162个，主要涉及的基因为IL6、TP53、VEGFA、TNF、CASP3；KEGG分析主要涉及通路为癌症通路、糖尿病并发症的AGE-RAGE信号通路、TNF信号通路、NF-κB信号通路、甲状腺激素信号通路等。 结论 药对“川楝子-延胡索”中含有多种不同成分，该成分可通过作用于相关基因及信号通路发挥治疗肝癌的作用。 |
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| AbstractList | R735.7; 目的 基于网络药理学方法研究药对"川楝子-延胡索"药理成分,分析该药对治疗肝癌的潜在分子机制.方法 借助相关数据库如TCMSP、Uniprot、Genecard等分别搜集中药川楝子、延胡索的有效成分、对应作用靶点以及疾病肝癌的靶点,选取药物、疾病交集靶点.此外,通过String、Metascape数据库筛选药物作用核心靶点并完成GO功能和KEGG通路富集分析.结果 中药川楝子、延胡索的有效成分分别为6、49个,共同成分1个;作用靶点分别为181、1097个,共同靶点143个;药对与肝癌的交集靶点162个,主要涉及的基因为IL6、TP53、VEGFA、TNF、CASP3;KEGG分析主要涉及通路为癌症通路、糖尿病并发症的AGE-RAGE信号通路、TNF信号通路、NF-κB信号通路、甲状腺激素信号通路等.结论 药对"川楝子-延胡索"中含有多种不同成分,该成分可通过作用于相关基因及信号通路发挥治疗肝癌的作用. 目的 基于网络药理学方法研究药对“川楝子-延胡索”药理成分，分析该药对治疗肝癌的潜在分子机制。 方法 借助相关数据库如TCMSP、Uniprot、Genecard等分别搜集中药川楝子、延胡索的有效成分、对应作用靶点以及疾病肝癌的靶点，选取药物、疾病交集靶点。此外，通过String、Metascape数据库筛选药物作用核心靶点并完成GO功能和KEGG通路富集分析。 结果 中药川楝子、延胡索的有效成分分别为6、49个，共同成分1个；作用靶点分别为181、1097个，共同靶点143个；药对与肝癌的交集靶点162个，主要涉及的基因为IL6、TP53、VEGFA、TNF、CASP3；KEGG分析主要涉及通路为癌症通路、糖尿病并发症的AGE-RAGE信号通路、TNF信号通路、NF-κB信号通路、甲状腺激素信号通路等。 结论 药对“川楝子-延胡索”中含有多种不同成分，该成分可通过作用于相关基因及信号通路发挥治疗肝癌的作用。 |
| Author | 唐东昕 龙奉玺 章甜 贾思静 杨柱 孙冬雪 |
| AuthorAffiliation | 贵州中医药大学研究生院,贵阳550025%贵州中医药大学第一附属医院肿瘤科,贵阳550001 |
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| Author_FL | ZHANG Tian SUN Dongxue YANG Zhu JIA Sijing TANG Dongxin LONG Fengxi |
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| Keywords | 肝肿瘤;药对;川楝子;延胡索 |
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| Publisher | Journal of Clinical Hepatology 贵州中医药大学研究生院,贵阳550025%贵州中医药大学第一附属医院肿瘤科,贵阳550001 |
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| Snippet | 目的 基于网络药理学方法研究药对“川楝子-延胡索”药理成分，分析该药对治疗肝癌的潜在分子机制。 方法... R735.7; 目的 基于网络药理学方法研究药对"川楝子-延胡索"药理成分,分析该药对治疗肝癌的潜在分子机制.方法... |
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| Title | 药对“川楝子-延胡索”治疗肝癌的网络药理学研究 |
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