Ketoprofen versus Diclofenac sodium in the treatment of renal colic

• Published in: Tunisie Medicale Vol. 95; no. 4; p. 286
• Main Authors: Jebali, Chawki, Boukadida, Lotfi, Chabaane, Wael, Haj Ali, Achref, Ousgi, Ali, Boukef, Riadh
• Format: Journal Article
• Language: English
• Published: Tunisia 01.04.2017
• Subjects: Adult; Anti-Inflammatory Agents, Non-Steroidal - therapeutic use; Diclofenac - therapeutic use; Double-Blind Method; Female; Humans; Ketoprofen - therapeutic use; Male; Renal Colic - drug therapy
• ISSN: 0041-4131

Adult renal colic is a frequent lombo-abdominal painful syndrome in emergencies. Treatment is based on nonsteroidal anti-inflammatory drug (NSAID) but the choice between different NSAIDs remains a subject of controversy. Our aim was to compare the efficacy and the safety of two intramuscularly NSAIDs in renal colic. We conducted a 32-week, randomized, double-blind, single-center study . Patients who had renal colic with a visual analogue scale (VAS) ≥ 5 were randomly assigned to receive, by intramuscularly injection, 100 mg of Ketoprofen (GK) or 75 mg of diclofenac (GD). If VAS > 3 after 40 minute, 1 g of paracetamol was administered as rescue analgesia. Primary endpoint was successful treatment. Secondary outcome was the occurrence of side effects. We have included 80 patients. the average age was 39 ± 13 years for GK versus 43 ± 14 years for GD. The mean VAS on admission was also similar in both arms. We objectified a therapeutic success rate of 92% in both groups. This success was similar in both arms. The use of rescue medication was 32.5% in the GK versus 47.5% in the GD (P=0.17). We have observed in 46% (n =37) of the study population side effects. These effects were only minor and no major intolerance expression was registered. the efficacy and tolerance of NSAIDs in the treatment of renal colic was the same for diclofenac and ketoprofen.