Genetic Subtypes and Status of Transmitted Drug Resistance of HIV/AIDS Patients in Sichuan

• Published in: Sichuan da xue xue bao. Journal of Sichuan University. Yi xue ban Vol. 53; no. 5; p. 851
• Main Authors: Liu, Huan-Xia, He, Sheng-Hua, Zhou, Rui-Feng, He, Yuan-Hong, Yang, Tong-Tong, Yao, Yuan
• Format: Journal Article
• Language: Chinese
• Published: China 01.09.2022
• Subjects: Acquired Immunodeficiency Syndrome - drug therapy; Acquired Immunodeficiency Syndrome - epidemiology; Adult; China - epidemiology; Drug Resistance, Viral - genetics; Genotype; HIV Infections - drug therapy; HIV Infections - epidemiology; HIV-1 - genetics; Humans; Integrase Inhibitors - pharmacology; Integrase Inhibitors - therapeutic use; Mutation; Phylogeny; Protease Inhibitors - pharmacology; Protease Inhibitors - therapeutic use; Reverse Transcriptase Inhibitors - pharmacology; Reverse Transcriptase Inhibitors - therapeutic use; RNA - pharmacology; RNA - therapeutic use; China; HIV/AIDS patients; Transmitted drug resistance; Antiretroviral therapy; Genotypes
• ISSN: 1672-173X
• DOI: 10.12182/20220960206

To investigate the distribution characteristics of the HIV genetic subtypes and the status quo of transmitted drug resistance among HIV/AIDS patients in Sichuan with no previous history of receiving antiretroviral therapy (ART). Adult HIV/AIDS patients who were hospitalized in Sichuan and who had no previous history of exposure to ART drugs exposure were enrolled. In-house sequencing of the HIV gene was done and phylogenetic tree was constructed to analyze the HIV genetic subtypes. The Stanford HIV drug resistance database was used to make online comparison of the drug resistance mutation sites and to determine the presence or absence of drug resistance, and the type and level of drug resistance. A total of 120 patients were enrolled for the study, and 120 blood samples were collected. The genetic subtypes of 87.5% (105/120) of the samples were successfully amplified. The distribution characteristics of HIV genotype were as follows, CRF01_AE accounted for 46.67% (49/105), CRF07_BC accounted for 39.05% (41/105