Long-term survival analysis of different breast cancer molecular subtypes: Shanghai Breast Cancer Survival Study

To analyze the survival of breast cancer molecular subtypes and to examine the effect of therapy on the long-term prognosis of different subtypes. This study included 3 586 breast cancer patients with estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor-2 (HE...

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Published inChung-hua wai kʿo tsa chih Vol. 53; no. 12; p. 928
Main Authors Bao, Pingping, Peng, Peng, Gu, Kai, Wu, Chunxiao, Huang, Zhezhou, Gong, Yangming, Zhang, Minlu, Zheng, Ying
Format Journal Article
LanguageChinese
Published China 01.12.2015
Subjects
Breast Neoplasms
Chemotherapy, Adjuvant
Cohort Studies
Disease-Free Survival
Humans
Immunohistochemistry
Prognosis
Proportional Hazards Models
Prospective Studies
Receptor, ErbB-2
Receptors, Estrogen
Receptors, Progesterone
Survival Rate
Triple Negative Breast Neoplasms
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Summary:To analyze the survival of breast cancer molecular subtypes and to examine the effect of therapy on the long-term prognosis of different subtypes. This study included 3 586 breast cancer patients with estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor-2 (HER2) information in Shanghai Breast Cancer Survival Study, a population-based prospective cohort study established in 2002. Molecular subtypes, based on immunohistochemistry were categorized as follows: Luminal A, Luminal B, HER2, and triple-negative subtype. Characteristics and clinical data were collected through questionnaires and medical records at baseline survey and sequential follow-up surveys. Survival rates of different molecular subtypes were analyzed and compared with Log-rank tests. Multiple Cox regression models were used to evaluate the effect of therapy on long-term prognosis of different molecular subtypes. Among the 3 586 cases, Luminal A, Luminal B, HER2 and triple-negative breast cancer subtypes a
ISSN:0529-5815