Relationship of B/A ratio and acidosis with abnormal brainstem auditory evoked potentials in neonates with severe hyperbilirubinemia

• Published in: Zhongguo dang dai er ke za zhi Vol. 15; no. 5; p. 332
• Main Authors: Zhuang, Yan, Li, Gui-Nan, Zhou, Yong, Hu, Yue-Yuan, Li, Jun, Zhan, Cai-Xia
• Format: Journal Article
• Language: Chinese
• Published: China 01.05.2013
• Subjects: Acidosis - physiopathology; Bilirubin - blood; Evoked Potentials, Auditory, Brain Stem; Humans; Hyperbilirubinemia - blood; Hyperbilirubinemia - physiopathology; Infant, Newborn; Serum Albumin - analysis
• ISSN: 1008-8830
• DOI: 10.7499/j.issn.1008-8830.2013.05.003

To investigate the relationship of bilirubin/albumin (B/A) ratio and acidosis with abnormal brainstem auditory evoked potentials (BAEPs) in neonates with severe hyperbilirubinemia and its clinical significance. A total of 967 neonates with severe hyperbilirubinemia between November 2008 and October 2009 were enrolled in the study. They were divided into two groups according to their BAEPs: normal BAEP group (n=799) and abnormal BAEP group (n=168). Univariate analysis and age-stratified Chi-square test were used to determine the relationship of B/A ratio and acidosis with BAEP. The univariate analysis showed that the abnormal BAEP group had significantly lower pH and base excess values and a significantly higher B/A ratio compared with the normal BAEP group (P<0.05). The age-stratified Chi-square test showed that neonates with acidosis or with a B/A ratio greater than 1.0 had a significantly higher incidence of abnormal BAEPs than those without acidosis or with a B/A ratio less than 1.0 in any age (days) group