Specific features of left ventricular remodeling in patients with diabetes mellitus and coronary heart disease residing in the Far North

• Published in: Klinicheskaia meditsina Vol. 90; no. 5; p. 28
• Main Authors: Kuznetsov, V A, Bessonova, M I, Bessonov, I S, Zyrianov, I P, Krinochkin, D V, Kolunin, G V, Semukhin, M V, Panin, A V, Bukhvalov, V A, Gorbatenko, E A
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 2012
• Subjects: Adult; Aged; Arctic Regions - epidemiology; Asia, Central - epidemiology; Coronary Disease - complications; Coronary Disease - epidemiology; Coronary Disease - physiopathology; Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - epidemiology; Diabetes Mellitus, Type 2 - physiopathology; Female; Humans; Hypertrophy, Left Ventricular - epidemiology; Hypertrophy, Left Ventricular - etiology; Hypertrophy, Left Ventricular - pathology; Hypertrophy, Left Ventricular - physiopathology; Male; Middle Aged; Ventricular Remodeling - physiology; Asia, Central; Arctic Regions
• ISSN: 0023-2149

This study enrolled 202 patients with diabetes mellitus and coronary heart disease residing in the Far North. They were selected from 8753 subjects included in the Registry of performed coronary angiographies. The control group contained 196 patients with CHD and DM2 residing in the south of Tyumen region. 76 (19%) patients had normal structural and functional characteristics of LV (LVMM = < N and LVRWT < 0.45), in 322 (81%) these characteristics were pathologically changed (eccentric and concentric LV hypertrophy, concentric LV remodeling). Groups 1 and 2 included 79.2 and 68.4% men respectively p = 0.014) of mean age 53.9 +/- 0.45 and 58.1 +/- 0.51 p < 0.001) having LV diameter 26.2 +/- 0.2 mm and 25.5 +/- 0.2 mm (p = 0.012). Other echocardiographic parameters, occurrence of asymmetric myocardial hypertrophy, and distribution of the patients by the types of LV geometric models were not significantly different. Odd ratios for the patients with pathological LV morphology revealed no dependence of LV remodeling on the site of residence. The structural and functional changes in myocardium of the patients residing in the North and South of Tyumen region were comparable in terms of severity. It is concluded that DM is a powerful factor influencing myocardial remodeling to the extent that masks even the effects of extreme ("northern") environmental conditions.