Study on the correlation between the inflammatory factors in the serum and the induced sputum and the hypothalamic-pituitary-adrenal axis function in advanced lung adenocarcinoma of different syndromes

• Published in: Zhongguo Zhong xi yi jie he za zhi Vol. 32; no. 7; p. 896
• Main Authors: Du, Yi-Jie, Cao, Yu-Xue, Duan, Xiao-Hong
• Format: Journal Article
• Language: Chinese
• Published: China 01.07.2012
• Subjects: Adenocarcinoma - blood; Adenocarcinoma - physiopathology; Adenocarcinoma of Lung; Adolescent; Adult; Aged; Case-Control Studies; Cytokines - blood; Female; Humans; Hypothalamo-Hypophyseal System - metabolism; Hypothalamo-Hypophyseal System - physiopathology; Inflammation; Lung Neoplasms - blood; Lung Neoplasms - physiopathology; Male; Middle Aged; Neoplasm Staging; Pituitary-Adrenal System - metabolism; Pituitary-Adrenal System - physiopathology; Sputum - chemistry; Young Adult
• ISSN: 1003-5370

To study the correlation between the inflammatory factors in the serum and the induced sputum and the hypothalamic-pituitary-adrenal (HPA) axis function in advanced lung adenocarcinoma patients of different syndromes. Totally 71 patients with advanced lung adenocarcinoma were assigned to three groups according to syndrome differentiation, i.e., Shen-yang deficiency (SYD) group (28 cases), Fei-qi deficiency (FQD) group (23 cases), and yin deficiency fire excess (YDFE) group (20 cases). Another 41 healthy subjects were enrolled as the normal control group. Sputum was induced and blood samples were collected for measurement of cytokines including tumor necrosis factor alpha (TNF-alpha), transforming growth factor beta (TGF-beta), interleukin-6 (IL-6), and interferon gamma (INF-gamma). The cytokine assay was performed using Bio-Plex Pro multi assay technology. 24-h collection of urine was performed and salivary samples of the diurnal rhythm profiles [including urinary free cortisol (UFC), urinary 17-hydroxycortic