Phytochemical and antifungal activities of Uvaria. chamae leaves and roots, Spondias mombin leaves and bark and Combretum racemosum leaves

The effects of crude and dilutions of aqueous, methanolic and n-hexane extracts of Uvaria chamae (roots and leaves), Spondias mombin (leaves and bark) and Combretum racemosum (Leaves), on pathogenic candida albicans and aspergillus niger was studied. The aim was to contribute to the search for a che...

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Bibliographic Details
Published inAfrican journal of medicine and medical sciences Vol. 41 Suppl; p. 99
Main Authors Okwuosa, O M T B, Chukwura, E I, Chukwuma, G O, Okwuosa, C N, Enweani, I B, Agbakoba, N R, Chukwuma, C M, Manafa, P O, Umedum, C U
Format Journal Article
LanguageEnglish
Published Nigeria 01.12.2012
Subjects
Alkaloids - pharmacology
Anacardiaceae - chemistry
Antifungal Agents - pharmacology
Aspergillus niger - drug effects
Candida albicans - drug effects
Combretum - chemistry
Dermatomycoses - drug therapy
Dermatomycoses - microbiology
Humans
Ketoconazole - pharmacology
Microbial Sensitivity Tests - methods
Phytotherapy
Plant Extracts
Plant Leaves
Plant Structures
Uvaria - chemistry
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Summary:The effects of crude and dilutions of aqueous, methanolic and n-hexane extracts of Uvaria chamae (roots and leaves), Spondias mombin (leaves and bark) and Combretum racemosum (Leaves), on pathogenic candida albicans and aspergillus niger was studied. The aim was to contribute to the search for a cheaper, conventional cure for both fungi. Phytochemical analysis revealed varying degrees of alkaloids, glycosides, saponin, lipid and oil, tannins, flavonoids, terpenoids and acids. Agar diffusion method was used for anti fungal assay. Minimum inhibitory concentration (mic) used was 10 mg/ml of extract and dilutions of the non polar solvents of 10 (-1) and 10(-2) was used. Results showed that none of the plant parts was active against aspergillus niger. Combretum racemosum had no antifungal effect on tested organisms as well as the different dilutions. However crude methanolic extract of uvaria (roots and leaves), spondias ( bark and leaves ), and n-hexane extracts of uvaria (leaves and roots), produced anti candidal effects with diameters in this order 14.67 +/- 0.72mm, 10.67 +/- 0.52 mm, 11.00 +/- 0.47 mm, 15.00 +/- 0.47 mm, and 14.67 +/- 0.72 mm respectively. Some of the plant parts especially uvaria had zones of inhibition at a confidence limit comparable with control drug which is ketoconazole and it had inhibitory effects at a diameter of 20.06 +/- 0.40 mm.
ISSN:0309-3913