Paclitaxel

• Published in: Profiles of drug substances, excipients, and related methodology Vol. 44; p. 205
• Main Authors: Alqahtani, Fulwah Yahya, Aleanizy, Fadilah Sfouq, El Tahir, Eram, Alkahtani, Hamad M, AlQuadeib, Bushra T
• Format: Journal Article
• Language: English
• Published: Netherlands 2019
• Subjects: Physicochemical; Taxus; Analysis; Paclitaxel; Cancer
• ISSN: 1871-5125
• DOI: 10.1016/bs.podrm.2018.11.001

Paclitaxel is the first microtubule-stabilizing agent identified and considered to be the most significant advance in chemotherapy of the past two decades. It is considered one of the most widely used antineoplastic agents with broad activity in several cancers including breast cancer, endometrial cancer, non-small-cell lung cancer, bladder cancer, and cervical carcinoma. It is also used for treating AIDS-related Kaposi sarcoma as a second line treatment. This comprehensive profile of paclitaxel gives overview of nomenclature, formulae, elemental analysis, appearance, application and uses. In addition, mechanism of action and resistance, different dosage forms and methods of drug preparation are elaborated. Moreover, the physicochemical properties involving X-ray powder diffraction pattern, drug solubility, melting point, differential scanning calorimetry, and stability were summarized. Furthermore, method of drug analysis including compendial, spectrophotometric, and chromatographic was discussed.