Participation of melatonin in change of nociception of snails and mice under influence of long-term electromagnetic shielding

Long-term electromagnetic shielding causes three-phase changes in nociception of snails and mice: an initial phase of the antinociceptive effect ofhyperalgesia is replaced with a further normalization of the parameters of nociception. These changes in snails develop slowly and phase of hyperalgesia...

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Bibliographic Details
Published inRossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova Vol. 99; no. 11; p. 1333
Main Authors Temur'iants, N A, Kostiuk, A S, Tumaniants, K N
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.11.2013
Subjects
Animals
Central Nervous System Depressants - pharmacology
Electromagnetic Fields
Helix (Snails) - physiology
Melatonin - pharmacology
Mice
Nociception - drug effects
Nociception - physiology
Species Specificity
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Summary:Long-term electromagnetic shielding causes three-phase changes in nociception of snails and mice: an initial phase of the antinociceptive effect ofhyperalgesia is replaced with a further normalization of the parameters of nociception. These changes in snails develop slowly and phase of hyperalgesia expressed more vividly than in mice. Daily injections of melatonin in animals eliminate shielding-induced hyperalgesia causes an earlier and more pronounced antinociceptive effect. Such changes are due, apparently, with the initial depression ofmelatonin secretion under the influence of the electromagnetic shielding, which leads to the development ofhyperalgesia. In the future, the secretion of melatonin increases, that is shown in the growth of antinociceptive effect.
ISSN:0869-8139