A Case of Small Intestinal GIST with Long-Term Survival after Tumor Resection for Repeated Peritoneal Recurrence

• Published in: Gan to kagaku ryoho Vol. 44; no. 12; p. 1521
• Main Authors: Terada, Yoshitaka, Sonoda, Hiromichi, Miyake, Toru, Shimizu, Tomoharu, Ueki, Tomoyuki, Takebayashi, Katsushi, Kaida, Sachiko, Yamaguchi, Tsuyoshi, Kitamura, Naomi, Iida, Hiroya, Akabori, Hiroya, Mori, Tsuyoshi, Tani, Masaji
• Format: Journal Article
• Language: Japanese
• Published: Japan 01.11.2017
• Subjects: Aged; Antineoplastic Agents - therapeutic use; Combined Modality Therapy; Female; Gastrointestinal Stromal Tumors - drug therapy; Gastrointestinal Stromal Tumors - secondary; Gastrointestinal Stromal Tumors - surgery; Humans; Imatinib Mesylate - therapeutic use; Intestinal Neoplasms - drug therapy; Intestinal Neoplasms - secondary; Intestine, Small - pathology; Intestine, Small - surgery; Peritoneal Neoplasms - drug therapy; Peritoneal Neoplasms - secondary; Peritoneal Neoplasms - surgery; Recurrence; Time Factors
• ISSN: 0385-0684

A 70-year-old woman presenting with abdominal pain was admitted to our hospital. Abdominal contrast CT revealed a small intestine tumor of 10 cm with active bleeding and performed partial resection of the small intestine including tumor. Pathological findings were high risk GIST of the small intestine because of spindle cells and c-kit positive. Imatinib 400mg/day as adjuvant chemotherapy was administered. However administration was stopped for 15 days because of the Grade 4 erythema multiforme. Recurrence of peritoneal dissemination was observed in 2 years after surgery and tumor resection was performed, but complete resection was difficult. Within 5 years after surgery, tumor resection was performed on a total of 5 times peritoneal disseminative recurrences, and it was possible to avoid the appearance of symptoms due to tumor augmentation.