A Case of Stage Ⅳ Gastric Cancer Completely Resected after Successful Second-Line Chemotherapy

A 60s man was diagnosed with advanced gastric cancer(cT4b[PAN], cN+, cM0, cStage ⅣA). He started first-line chemotherapy consisting of S-1 and cisplatin, but tumor markers remained elevated and CT showed cancer progression. He then started second-line chemotherapy consisting of ramucirumab and pacli...

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Bibliographic Details
Published inGan to kagaku ryoho Vol. 49; no. 13; p. 1899
Main Authors Kidogami, Shinya, Kawada, Junji, Fujita, Junya, Tamura, Shigeyuki, Mizuno, Manatsu, Nakano, Masaya, Fukada, Akio, Nagano, Shinnosuke, Mokutani, Yukako, Kishimoto, Tomoya, Hashimoto, Yasuji, Hirose, Hajime, Yoshioka, Shinichi, Sasaki, Yoh
Format Journal Article
LanguageJapanese
Published Japan 01.12.2022
Subjects
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Cisplatin - therapeutic use
Gastrectomy
Humans
Male
Paclitaxel - therapeutic use
Stomach Neoplasms - drug therapy
Stomach Neoplasms - pathology
Stomach Neoplasms - surgery
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Summary:A 60s man was diagnosed with advanced gastric cancer(cT4b[PAN], cN+, cM0, cStage ⅣA). He started first-line chemotherapy consisting of S-1 and cisplatin, but tumor markers remained elevated and CT showed cancer progression. He then started second-line chemotherapy consisting of ramucirumab and paclitaxel. The tumor markers decreased, and CT revealed tumor regression. A distal gastrectomy with D2 lymph node dissection was performed as conversion surgery. The patient had an uncomplicated postoperative course and was discharged early from the hospital. A histological analysis confirmed complete resection of the Grade 1a tumor. The RAM plus PTX regimen was restarted on postoperative day 57. At 15 months postoperative, the patient remained alive and relapse-free.
ISSN:0385-0684