Clinicopathologic features of primary thymic extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue type

• Published in: Zhonghua bing li xue za zhi Vol. 41; no. 4; p. 234
• Main Authors: Sun, Lu, Shi, Huai-yin, Wei, Li-xin
• Format: Journal Article
• Language: Chinese
• Published: China 01.04.2012
• Subjects: Adult; Antibodies, Monoclonal, Murine-Derived - therapeutic use; Antigens, CD20 - metabolism; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Cyclophosphamide - therapeutic use; Diagnosis, Differential; Doxorubicin - therapeutic use; Female; Follow-Up Studies; Gene Rearrangement, B-Lymphocyte, Heavy Chain; Humans; Immunoglobulin Heavy Chains - genetics; Keratin-19 - metabolism; Lymphoma, B-Cell, Marginal Zone - drug therapy; Lymphoma, B-Cell, Marginal Zone - genetics; Lymphoma, B-Cell, Marginal Zone - metabolism; Lymphoma, B-Cell, Marginal Zone - pathology; Lymphoma, B-Cell, Marginal Zone - surgery; Male; Prednisone - therapeutic use; Pseudolymphoma - pathology; Thymus Hyperplasia - pathology; Thymus Neoplasms - drug therapy; Thymus Neoplasms - genetics; Thymus Neoplasms - metabolism; Thymus Neoplasms - pathology; Thymus Neoplasms - surgery; Vincristine - therapeutic use
• ISSN: 0529-5807
• DOI: 10.3760/cma.j.issn.0529-5807.2012.04.005

To study the clinicopathologic features of primary thymic extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT). The clinical and pathologic findings were evaluated in 3 cases of biopsy confirmed thymic MALT lymphoma. The clincopathologic features, treatment and prognosis were discussed and literatures reviewed. One male and two female patients presented with asymptomatic mediastinal masses with a history of Sjögren syndrome. They were aged 36, 35 and 41 years respectively, and only one patient had B symptoms. Grossly, all three tumors were encapsulated and had multiple variable-sized cysts on cut-surface. Histopathologically, the normal thymic lobular architecture was effaced by abnormal dense lymphoid infiltration. Prominent lymphoepithelial lesions were formed by centrocyte-like cells infiltrating and expanding Hassall's corpuscles and epithelial cyst lining. All cases showed apparent plasmacytic differentiation. Immunohistochemically, the tumor cells were positive for CD20,