Genotype-phenotype characteristics of biochemical markers of endothelial dysfunction in patients with chronic mercury intoxication

The paper presents data on the frequency of polymorphisms of candidate genes involved in the formation of endothelial dysfunction--endothelin-1 (EDN1 Lys198Asn) and endothelial nitric oxide synthase (NOS3 T786C) together with the concentrations of their active products (nitric oxide, endothelin-1) i...

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Bibliographic Details
Published inMeditsina truda i promyshlennaia ekologiia no. 4; p. 19
Main Authors Popkova, O V, Kudaeva, I V, Masnavieva, L B, Belik, V P
Format Journal Article
LanguageRussian
Published Russia (Federation) 2014
Subjects
Biomarkers - blood
Chronic Disease
Endothelin-1 - blood
Endothelin-1 - genetics
Endothelium - physiopathology
Genotype
Humans
Male
Mercury Poisoning - blood
Mercury Poisoning - genetics
Middle Aged
Nitric Oxide - blood
Nitric Oxide - metabolism
Nitric Oxide Synthase Type III - genetics
Occupational Diseases - blood
Occupational Diseases - genetics
Occupational Exposure - adverse effects
Phenotype
Polymorphism, Genetic
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Summary:The paper presents data on the frequency of polymorphisms of candidate genes involved in the formation of endothelial dysfunction--endothelin-1 (EDN1 Lys198Asn) and endothelial nitric oxide synthase (NOS3 T786C) together with the concentrations of their active products (nitric oxide, endothelin-1) in individuals with chronic mercury intoxication. The concentration change of nitric oxide and endothelin-1 indicates the presence of endothelial dysfunction in the individuals examined. The studied polymorphisms appeared to play a minor role in the pathogenesis of endothelial dysfunction in patients with chronic mercury intoxication.
ISSN:1026-9428