Analysis of HPA gene Polymorphisms in Children with Acute or Chronic ITP

To investigate the frequency distribution of human platelet antigen allele HPA-2 and HPA-15 among the pediatric patients with acute or chronic idiopathic thrombocytopenic purpura (ITP) in Chinese Guangxi area, and to explore the potential correlation of ITP with HPA-2 and HPA-15 gene polymorphisms....

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Published inZhongguo shi yan xue ye xue za zhi Vol. 24; no. 5; p. 1518
Main Authors Tang, Li-Juan, Zhou, Xiao-Heng, Bin, Qiong, Huang, Xiao-Hua, Luo, Jiang-Ming
Format Journal Article
LanguageChinese
Published China 01.10.2016
Subjects
Alleles
Antigens, Human Platelet
Asian Continental Ancestry Group
Child
China
Chronic Disease
Gene Frequency
Genotype
Humans
Polymerase Chain Reaction
Polymorphism, Genetic
Purpura, Thrombocytopenic, Idiopathic
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Summary:To investigate the frequency distribution of human platelet antigen allele HPA-2 and HPA-15 among the pediatric patients with acute or chronic idiopathic thrombocytopenic purpura (ITP) in Chinese Guangxi area, and to explore the potential correlation of ITP with HPA-2 and HPA-15 gene polymorphisms. The clinical and laboratorial data of 46 children diagnosed as acute ITP and 46 children diagnosed as chronic ITP between January 2007 and December 2014 were collected. Genotyping of HPA-2 and HPA-15 in 92 ITP patients and 48 healthy controls was performed by using polymerase chain reaction (PCR) combined with direct sequencing. The allele frequencies of HPA-2 and HPA-15 were significantly different among the acute, chronic and control groups; the allele frequencies were significantly different between the chronic ITP group and the control group (P<0.0167), while the difference was not statistically significant between the acute and chronic ITP groups as well as between the acute ITP and the control group (P>0.0167
ISSN:1009-2137
DOI:10.7534/j.issn.1009-2137.2016.05.042