An autopsy of G-CSF-producing anaplastic carcinoma of the pancreas with impaired accumulation on FDG-PET after S-1 chemotherapy

This paper presents a woman in her 70's with G-CSF producing anaplastic carcinoma of the pancreas(Stage IVb)who underwent chemotherapy by S-1 alone. On FDG-PET after the first course, accumulation of FDG was impaired remarkably. After the second course, the patient died of carcinomatous pleurit...

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Bibliographic Details
Published inGan to kagaku ryoho Vol. 40; no. 6; p. 789
Main Authors Ikeda, Shohei, Okubo, Kenji, Shibahara, Hiroaki, Narita, Michihiko, Morita, Kiyoshi, Takeuchi, Atsufumi, Kanazawa, Hironobu, Ito, Takanori, Nishimura, Daisaku, Katada, Naoyuki
Format Journal Article
LanguageJapanese
Published Japan 01.06.2013
Subjects
Aged
Antimetabolites, Antineoplastic - therapeutic use
Autopsy
Carcinoma - diagnostic imaging
Carcinoma - drug therapy
Carcinoma - metabolism
Drug Combinations
Fatal Outcome
Female
Fluorodeoxyglucose F18
Granulocyte Colony-Stimulating Factor - biosynthesis
Humans
Oxonic Acid - therapeutic use
Pancreatic Neoplasms - diagnostic imaging
Pancreatic Neoplasms - drug therapy
Pancreatic Neoplasms - metabolism
Pleurisy - etiology
Positron-Emission Tomography
Tegafur - therapeutic use
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Summary:This paper presents a woman in her 70's with G-CSF producing anaplastic carcinoma of the pancreas(Stage IVb)who underwent chemotherapy by S-1 alone. On FDG-PET after the first course, accumulation of FDG was impaired remarkably. After the second course, the patient died of carcinomatous pleuritis and peritonitis on the 88th day after initiation of treatment. G-CSF producing anaplastic carcinoma of the pancreas is extremely rare and there are no reports with regard to response evaluation by FDG-PET. Thus, this case has significant clinical value.
ISSN:0385-0684