A Case of Metachronous Liver Metastases of Gall Bladder Cancer Successfully Treated by Liver Resection

• Published in: Gan to kagaku ryoho Vol. 43; no. 12; p. 2092
• Main Authors: Asai, Kensuke, Murata, Masaru, Saso, Kazuhiro, Yamada, Moyuru, Sawami, Hirokazu, Suzuki, Rei, Fukunaga, Hiroki, Tanaka, Nobuo, Yamamoto, Masayuki, Hiratsuka, Masahiro
• Format: Journal Article
• Language: Japanese
• Published: Japan 01.11.2016
• Subjects: Aged; Antimetabolites, Antineoplastic - therapeutic use; Chemotherapy, Adjuvant; Cholecystectomy; Deoxycytidine - analogs & derivatives; Deoxycytidine - therapeutic use; Female; Gallbladder Neoplasms - drug therapy; Gallbladder Neoplasms - pathology; Gallbladder Neoplasms - surgery; Hepatectomy; Humans; Liver Neoplasms - drug therapy; Liver Neoplasms - secondary; Liver Neoplasms - surgery
• ISSN: 0385-0684

A 73-year-old woman was diagnosed with gall bladder cancer by contrast enhanced CT images.The tumor was detected at the fundus of the gall bladder and enhanced heterogeneously.She underwent radical cholecystectomy including Japanese D2 lymph node dissection for gall bladder cancer.After 4 courses of oral S-1(80mg/m2 administered for 4 weeks and then stopped for 2 weeks)as adjuvant chemotherapy, a liver metastasis at segment 5 appeared 11 months postoperatively.It showed a ring enhanced tumor on contrast enhanced CT images.FDG accumulated in a similar lesion on PET-CT images.The patient successfully underwent partial hepatectomy of segment 5 of the liver.However, another liver metastasis at segment 7 appeared 5 months after the second operation, but it was resected successfully.The primary lesion and both liver metastases showed similar microscopic appearances.Seven courses of gemcitabine therapy(gemcitabine 1,000mg/m2 once every week for 3 weeks and then stopped for 1 week)were administered as adjuvant chemotherapy.She is now doing well without any sign of recurrence 2 years after the initial operation and 14 months after the secondary liver resection.