Analysis of Hematopoietic Reconstitution in Auto-Peripheral Blood Hematopoietic Stem Cell Transplantation

• Published in: Zhongguo shi yan xue ye xue za zhi Vol. 25; no. 5; p. 1518
• Main Authors: Chen, Ying-Ying, Zhao, Xiao-Li, Li, Hong-Hua, Bo, Jian, Zhao, Yu, Jing, Yu, Wang, Quan-Shun, Gao, Chun-Ji, Yu, Li, Huang, Wen-Rong
• Format: Journal Article
• Language: Chinese
• Published: China 01.10.2017
• Subjects: Antigens, CD34; Blood Platelets; Cell Count; Glycosides; Hematopoietic Stem Cell Transplantation; Humans; Neutrophils; Peripheral Blood Stem Cell Transplantation; Pregnanes
• ISSN: 1009-2137
• DOI: 10.7534/j.issn.1009-2137.2017.05.042

To explore the factors which may have influences on hematopoietic reconstitution of the auto-peripheral blood stem cell transplantation(auto-PBHSCT). The successful rate, the time of hematopoietic reconstitution and implantation status at 28 days after transplantation of 177 patients received auto-PBSCT were retropectively analyzed, in order to explore the factors which may have influences on hematopoietic reconstitution. The median time of neutrophil recovery was 12 days (8-21 days), implantation rate was 98.9%, all patients' neutrophil were recovered in 28 days. The median time of platelet recovery was 17 days (7-420 days), implantation rate was 95.5%, the cumulative incidence of platelet recovery at day 28 was 80.8%. Univariate analysis showed that the CD34 cell number and the use of TPO had effect on neutrophils recovery time; the disease kinds, conditioning regimen and the infused CD34 cell number had influence on platelets recovery time. Multivariate analysis showed that the CD34 cell number was the ind